Arrange the beef bones on a rimmed baking sheet or roasting pan.
Roast the beef bones for 20 minutes; turn and continue to roast for 20 minutes longer.
Meanwhile, add 10 cups of the water along with the vinegar to the Instant Pot. Choose the sauté button and bring the water to a boil. Add the bones to the boiling water and continue to boil for 15 minutes.